The effects of BMMSC treatment on lung tissue degeneration in elderly macaques

Abstract Background Age-associated lung tissue degeneration is a risk factor for injury and exacerbated disease. It also the main chronic diseases (such as COPD, idiopathic pulmonary fibrosis, cancer, among others). So, it particularly important to find new anti-aging treatments. Methods We systematically screened evaluated elderly senile multiple organ dysfunction macaque models determine whether BMMSCs inhibited degeneration. Results The average alveolar area, mean linear intercept (MLI), fibrosis area in were significantly larger than young rhesus monkeys ( p < 0.05), while capillary density around alveoli was low 0.05). Intravenous infusion of reduced degree increased capillaries number type II epithelium macaques In addition, ROS levels, systemic inflammatory Treg cell ratio Indirect co-cultivation revealed that suppressed expression senescence-associated genes, apoptosis rate aging epithelial cells (A549 cells), enhanced their proliferation Conclusions BMMSC treatment age-associated